MOSCOW- Russian President Vladimir Putin has clearly indicated that the transfer of Tomahawk missiles to Kyiv will inflict irreparable damage on relations between Moscow and Washington, Russian Foreign Ministry Spokeswoman Maria Zakharova said on Wednesday.

"I repeat, if the US administration ultimately makes the relevant decision, it will not only risk escalating the spiral of confrontation, but also inflict irreparable damage on Russian-US relations, which have just begun to show elements of resuming bilateral dialogue," she said, adding that the Russian leadership has addressed this matter on numerous occasions.

Zakharova noted that Russia is closely monitoring the situation surrounding Tomahawk missiles, urging the United States to exercise restraint.

"We call for the exercise of maximum restraint when dealing with this highly sensitive topic, one that could significantly complicate efforts to find a way out of the situation in Ukraine, and we hope that our signals will be heard in Washington," Zakharova said. 

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Separately, three people were killed and several others injured in a Ukrainian shelling and drone attack on Russia's border region of Belgorod, Governor Vyacheslav Gladkov said on Wednesday.

"The settlement of Maslova Pristan in the Shebekinsky District came under shelling. According to preliminary information, three people lost their lives and one was injured," Gladkov wrote on Telegram, adding that a social facility had been partially damaged.

The governor said Ukrainian armed forces had attacked populated areas across the Belgorod region with more than 110 unmanned aerial vehicles and fired over 20 rounds of munitions in the past 24 hours.

Residential areas in the Grayvoronsky District were hit by 16 drones and nine rounds of munitions, he said.

"In the village of Moshchenoye, six people, including a child, were injured in a projectile and drone attack on a truck. A four-year-old girl was taken to the regional children's clinical hospital, where she was examined -- barotrauma was not confirmed," he said

"Six adults were hospitalized, while one of the injured continued outpatient treatment," Gladkov added. Another civilian was wounded in a drone strike on a motor vehicle and is currently being treated in hospital, and a private home was also damaged, he added.

Gladkov said multiple other locations across the region had come under attack by Ukrainian drones and other means, leaving several people injured.